Also means
on the whole
Usage Note
im Großen und Ganzen is a fixed phrase summing up an overall impression while ignoring details, like by and large. It prefaces a general verdict: Im Großen und Ganzen war es gelungen.
Examples
"Im Großen und Ganzen bin ich zufrieden."
Natural Translation
By and large I'm satisfied.
Literal Translation
In-the big and whole am I satisfied.

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